Article
Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function.
Gastroenterology - 1 Aug 2008
Semela David, Das Amitava, Langer Daniel, Kang Ningling, Leof Edward, Shah Vijay
Abstract excerpt
BACKGROUND & AIMS: Cirrhosis is associated with prominent changes in sinusoidal structure and function. Although the resident pericyte in liver, the hepatic stellate cell (HSC), is well characterized in the process of fibrogenesis, signaling pathways that regulate HSC vascular function are less developed. Because pericyte populations outside the liver are increasingly being recognized as a key cell type for...
Topics
- Animals
- Becaplermin
- Benzamides
- Capillary Permeability
- Cells, Cultured
- Coculture Techniques
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Endothelial Cells
- Ephrin-B2
- Humans
- Hypertension, Portal
- Image Processing, Computer-Assisted