Article
Nemo-like kinase regulates postnatal skeletal homeostasis.
Journal of cellular physiology - 1 Nov 2014
Canalis Ernesto, Kranz Lauren, Zanotti Stefano
Abstract excerpt
Nemo-like kinase (Nlk) is related to the mitogen-activated protein (MAP) kinases and known to regulate signaling pathways involved in osteoblastogenesis. In vitro Nlk suppresses osteoblastogenesis, but the consequences of the Nlk inactivation in the skeleton in vivo are unknown. To study the function of Nlk, Nlk(loxP/loxP) mice, where the Nlk exon2 is flanked by lox(P) sequences, were mated with mice expressing...
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