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Article

Mesenchymal Deletion of Histone Demethylase NO66 in Mice Promotes Bone Formation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2015

Chen Qin, Sinha Krishna, Deng Jian Min, Yasuda Hideyo, Krahe Ralf, Behringer Richard R, de Crombrugghe Benoit

Abstract excerpt

Our previous studies indicated that the Jumonji C (JmjC)-domain-containing NO66 is a histone demethylase with specificity for methylated histone H3K4 and H3K36. NO66 binds to the transcription factor Osterix (Osx) and inhibits its transcriptional activity in promoter assays. However, the physiological role of NO66 in formation of mammalian bones is unknown. Here, using a genetically engineered mouse model, we...

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Identifiers

PMID: 25736226
DOI: 10.1002/jbmr.2494
PMCID: PMC4780322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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