Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO.

Abstract excerpt

Inflammatory osteolysis is governed by exacerbated osteoclastogenesis. Ample evidence points to central role of NF-κB in such pathologic responses, yet the precise mechanisms underpinning specificity of these responses remain unclear. We propose that motifs of the scaffold protein IKKγ/NEMO partly facilitate such functions. As proof-of-principle, we used site-specific mutagenesis to examine the role of NEMO in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone Marrow Cells
• Share to Inflammation
• Share to Intracellular Signaling Peptides and Proteins