Single nucleotide polymorphisms in Plasmodium falciparum V type H(+) pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms.

doi:10.1016/j.meegid.2014.03.004

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Article

Single nucleotide polymorphisms in Plasmodium falciparum V type H(+) pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jun 2014

Jovel Irina Tatiana, Ferreira Pedro Eduardo, Veiga Maria Isabel, Malmberg Maja, Mårtensson Andreas, Kaneko Akira, Zakeri Sedigheh, Murillo Claribel, Nosten Francois, Björkman Anders, Ursing Johan

Abstract excerpt

BACKGROUND: Chloroquine resistance in Plasmodium falciparum malaria has been associated with pfcrt 76T (chloroquine resistance transporter gene) and pfmdr1 86Y (multidrug resistance gene 1) alleles. Pfcrt 76T enables transport of protonated chloroquine out of the parasites digestive vacuole resulting in a loss of hydrogen ions (H(+)). V type H(+) pyrophosphatase (PfVP2) is thought to pump H(+) into the digestive...

Topics

Adult
Alleles
Antimalarials
Base Sequence
Child
Chloroquine
DNA, Protozoan
Drug Resistance
Genetic Linkage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

Humans

Inorganic Pyrophosphatase

Malaria, Falciparum

Membrane Transport Proteins

Multidrug Resistance-Associated Proteins

Plasmodium falciparum

Polymorphism, Single Nucleotide

Protozoan Proteins

Source

Open in PubMed

Identifiers

PMID: 24657918
DOI: 10.1016/j.meegid.2014.03.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24657918-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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