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Article

Plasmodium falciparum genotypes associated with chloroquine and amodiaquine resistance in Guinea-Bissau.

The American journal of tropical medicine and hygiene - 1 May 2007

Ursing Johan, Kofoed Poul-Erik, Rodrigues Amabelia, Rombo Lars, Gil José Pedro

Abstract excerpt

Chloroquine is the most commonly used antimalarial in Guinea-Bissau and high doses are routinely prescribed. Blood from 497 patients treated with different doses of chloroquine or amodiaquine were genotyped. Pfcrt and pfmdr1 polymorphisms were identified. Pfmsp2 analysis identified recrudescent infections. The pfcrt 72-76 haplotypes were CVIET and CVMNK. The pfcrt 76T prevalence was 23% at day 0 and 96%, 83% and...

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PMID: 17488902

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