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Article

Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda.

Malaria journal - 21 Mar 2017

Tukwasibwe Stephen, Tumwebaze Patrick, Conrad Melissa, Arinaitwe Emmanuel, Kamya Moses R, Dorsey Grant, Nsobya Samuel L, Greenhouse Bryan, Rosenthal Philip J

Abstract excerpt

BACKGROUND: Plasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcrt K76T, pfmdr1 N86Y, or pfmdr1 D1246Y had about one-fourth the odds of symptomatic malaria compared to those with infections with wild type (WT) sequences. However, results may have been confounded by greater likelihood...

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Identifiers

PMID: 28327148
DOI: 10.1186/s12936-017-1777-0
PMCID: PMC5361791

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Source receipt: pubmed, retrieved 7 Sept 2026.

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