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Article

Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia.

Biological psychiatry - 1 Apr 2006

Arai Makoto, Yamada Kazuo, Toyota Tomoko, Obata Nanako, Haga Seiichi, Yoshida Yuuki, Nakamura Kazuhiko, Minabe Yoshio, Ujike Hiroshi, Sora Ichiro, Ikeda Kazuhiko, Mori Norio, Yoshikawa Takeo, Itokawa Masanari

Abstract excerpt

BACKGROUND: Sialyltransferase 8B (SIAT8B) and 8D (SIAT8D) are two polysialyltransferases that catalyze the transfer of polysialic acid (PSA) to the neural cell adhesion molecule 1 (NCAM1). PSA modification of NCAM1 plays an important role in neurodevelopment of the brain and disruption of this process is postulated as an etiologic factor in psychiatric disorders. Altered levels of the PSA-NCAM1 in the brain of...

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Source

Identifiers

PMID: 16229822
DOI: 10.1016/j.biopsych.2005.08.016

Genes

NCAM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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