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Article

Lack of detectable HIV-1 molecular evolution during suppressive antiretroviral therapy.

PLoS pathogens - 1 Mar 2014

Kearney Mary F, Spindler Jonathan, Shao Wei, Yu Sloane, Anderson Elizabeth M, O'Shea Angeline, Rehm Catherine, Poethke Carry, Kovacs Nicholas, Mellors John W, Coffin John M, Maldarelli Frank

Abstract excerpt

A better understanding of changes in HIV-1 population genetics with combination antiretroviral therapy (cART) is critical for designing eradication strategies. We therefore analyzed HIV-1 genetic variation and divergence in patients' plasma before cART, during suppression on cART, and after viral rebound. Single-genome sequences of plasma HIV-1 RNA were obtained from HIV-1 infected patients prior to cART...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24651464
DOI: 10.1371/journal.ppat.1004010
PMCID: PMC3961343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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