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Article

An increasing proportion of monotypic HIV-1 DNA sequences during antiretroviral treatment suggests proliferation of HIV-infected cells.

Journal of virology - 1 Feb 2013

Wagner Thor A, McKernan Jen L, Tobin Nicole H, Tapia Ken A, Mullins James I, Frenkel Lisa M

Abstract excerpt

Understanding how HIV-1 persists during effective antiretroviral therapy (ART) should inform strategies to cure HIV-1 infection. We hypothesize that proliferation of HIV-1-infected cells contributes to persistence of HIV-1 infection during suppressive ART. This predicts that identical or monotypic HIV-1 DNA sequences will increase over time during ART. We analyzed 1,656 env and pol sequences generated following...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to env Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 23175380
DOI: 10.1128/JVI.01985-12
PMCID: PMC3554159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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