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Article

HD chromoendoscopy coupled with DNA mass spectrometry profiling identifies somatic mutations in microdissected human proximal aberrant crypt foci.

Molecular cancer research : MCR - 1 Jun 2014

Drew David A, Devers Thomas J, O'Brien Michael J, Horelik Nicole A, Levine Joel, Rosenberg Daniel W

Abstract excerpt

UNLABELLED: Despite increased implementation of screening colonoscopy, interval cancers in the proximal colon remain a major public health concern. This fact underscores the limitations of current screening paradigms and the need for developing advanced endoscopic techniques. The density of aberrant crypt foci (ACF), the earliest identifiable mucosal abnormality, may serve as a surrogate marker for colon cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24651453
DOI: 10.1158/1541-7786.MCR-13-0624
PMCID: PMC4058342

Genes

APC
EGFR
FLT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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