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Article

A 24-base-pair sequence 3' to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer.

1 May 1993

Abstract excerpt

Erythropoietin (Epo) synthesis increases in response to hypoxia. The hepatoma cell line Hep 3B produces low basal levels of Epo mRNA which increase markedly with hypoxia. To define the sequences necessary for this response, we linked fragments of the human Epo gene to a luciferase vector, introduced these plasmids into Hep 3B cells and assayed for luciferase activity after growth in 1% or 21% oxygen. A 621-bp Epo...

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Identifiers

PMID: 8387202
DOI: 10.1073/pnas.90.9.3928

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A 24-base-pair sequence 3' to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer.PMID 8387202Read ↗

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.Semantic proximity Read ↗

Enhancer element at the 3'-flanking region controls transcriptional response to hypoxia in the human erythropoietin geneSemantic proximity Read ↗

Regulation of the erythropoietin geneSemantic proximity Read ↗

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.Semantic proximity Read ↗

A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional ActivationSemantic proximity Read ↗

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.Semantic proximity Read ↗

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.Semantic proximity Read ↗

Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genesSemantic proximity Read ↗

Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice.Semantic proximity Read ↗

Translation of the human erythropoietin transcript is regulated by an upstream open reading frame in response to hypoxiaSemantic proximity Read ↗

Cloning of the human erythropoietin receptor geneSemantic proximity Read ↗

Functional characterization of transcription factor binding sites for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the human prothrombin gene enhancer.Semantic proximity Read ↗

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