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Article

The bigger picture of FTO: the first GWAS-identified obesity gene.

Nature reviews. Endocrinology - 1 Jan 2014

Loos Ruth J F, Yeo Giles S H

Abstract excerpt

Single nucleotide polymorphisms (SNPs) that cluster in the first intron of fat mass and obesity associated (FTO) gene are associated obesity traits in genome-wide association studies. The minor allele increases BMI by 0.39 kg/m(2) (or 1,130 g in body weight) and risk of obesity by 1.20-fold. This association has been confirmed across age groups and populations of diverse ancestry; the largest effect is seen in...

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Share to Alleles
Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Obesity

Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 24247219
DOI: 10.1038/nrendo.2013.227
PMCID: PMC4188449

Genes

FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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