Article

Differential activation of P-TEFb complexes in the development of cardiomyocyte hypertrophy following activation of distinct GPCRs

2020-02-12

Abstract excerpt

Pathological cardiac hypertrophy is driven by neurohormonal activation of specific G protein-coupled receptors (GPCRs) in cardiomyocytes and is accompanied by large-scale changes in cardiomyocyte gene expression. These transcriptional changes require activity of positive transcription elongation factor b (P-TEFb), which is recruited to target genes by the bromodomain protein Brd4 or the S uper E longation C omp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9ce26852-e590-52b6-9a64-a868ade4388c
DOI: 10.1101/2020.02.10.943209

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differential activation of P-TEFb complexes in the development of cardiomyocyte hypertrophy following activation of distinct GPCRsDOI 10.1101/2020.02.10.943209Read

BET Protein-Mediated Transcriptional Regulation in Heart FailureSemantic proximity Read

BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failureSemantic proximity Read

BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes.Semantic proximity Read

Transcription Factors in Heart: Promising Therapeutic Targets in Cardiac HypertrophySemantic proximity Read

Regulation of Cardiac Transcription Factor GATA4 by Post-Translational Modification in Cardiomyocyte Hypertrophy and Heart FailureSemantic proximity Read

BET bromodomain proteins regulate transcriptional reprogramming in genetic dilated cardiomyopathySemantic proximity Read

BRD4 Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult CardiomyocytesSemantic proximity Read

Nuclear GPCRs in cardiomyocytes: an insider's view of β-adrenergic receptor signaling.Semantic proximity Read

Role of the estrogen/estrogen-receptor-beta axis in the genomic response to pressure overload-induced hypertrophySemantic proximity Read

Cooperative Binding of ETS2 and NFAT Links Erk1/2 and Calcineurin Signaling in the Pathogenesis of Cardiac HypertrophySemantic proximity Read

The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophySemantic proximity Read

Signaling from β1‐ and β2‐adrenergic receptors is defined by differential interactions with PDE4Semantic proximity Read