Article
PKCepsilon-PKD1 signaling complex at Z-discs plays a pivotal role in the cardiac hypertrophy induced by G-protein coupling receptor agonists.
Biochemical and biophysical research communications - 25 Feb 2005
Iwata Miki, Maturana Andrés, Hoshijima Masahiko, Tatematsu Kenji, Okajima Toshihide, Vandenheede Jackie R, Van Lint Johan, Tanizawa Katsuyuki, Kuroda Shun'ichi
Abstract excerpt
Cardiac hypertrophy is triggered in response to mechanical stress and various neurohumoral factors, such as G-protein coupling receptor (GPCR) and gp130 cytokine receptor agonists. Recent studies have suggested cardiac Z-disc plays a pivotal role to regulate these cellular responses. Here, we demonstrate stimulations with GPCR agonists (norepinephrine, angiotensin II, and endothelin 1) and phorbol ester activated...
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