Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Herpes simplex virus type 1 ICP0 induces CD83 degradation in mature dendritic cells independent of its E3 ubiquitin ligase function.

The Journal of general virology - 1 Jun 2014

Heilingloh Christiane S, Mühl-Zürbes Petra, Steinkasserer Alexander, Kummer Mirko

Abstract excerpt

Mature dendritic cells (mDCs) are the most potent antigen-presenting cells known today, as they are the only antigen-presenting cells able to induce naïve T-cells. Therefore, they play a crucial role during the induction of effective antiviral immune responses. Interestingly, the surface molecule CD83 expressed on mDCs is targeted by several viruses. As CD83 has been shown to exert co-stimulatory functions on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD83 Antigen
Share to Herpesvirus 1, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immediate-Early Proteins

Share to Immune Evasion

Share to Immunoglobulins

Share to Proteasome Endopeptidase Complex

Share to Proteolysis

Share to Ubiquitination

Source

Identifiers

PMID: 24643878
DOI: 10.1099/vir.0.062810-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Herpes simplex virus type 1 ICP0 induces CD83 degradation in mature dendritic cells independent of its E3 ubiquitin ligase function.PMID 24643878Read ↗

Mature dendritic cells infected with herpes simplex virus type 1 exhibit inhibited T-cell stimulatory capacity.Semantic proximity Read ↗

Expression of ICP0 is sufficient to trigger natural killer cell recognition of herpes simplex virus-infected cells by natural cytotoxicity receptors.Semantic proximity Read ↗

Adenoviruses Activate Human Dendritic Cells without Polarization toward a T-Helper Type 1-Inducing SubsetSemantic proximity Read ↗

CD83 acts as immediate early response gene in activated macrophages and exhibits specific intracellular trafficking properties.Semantic proximity Read ↗

Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo.Semantic proximity Read ↗

Efficient transduction of mature CD83+ dendritic cells using recombinant adenovirus suppressed T cell stimulatory capacity.Semantic proximity Read ↗

CD83 and GRASP55 interact in human dendritic cells.Semantic proximity Read ↗

Low CD83, but normal MHC class II and costimulatory molecule expression, on spleen dendritic cells from HIV+ patients.Semantic proximity Read ↗

ICP0 induces the accumulation of colocalizing conjugated ubiquitin.Semantic proximity Read ↗

Determination of the inhibitory activity and biological half-live of soluble CD83: comparison of wild type and mutant isoforms.Semantic proximity Read ↗

CD83 is a dimer: Comparative analysis of monomeric and dimeric isoforms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.