Characterization of Chilean patients with sporadic colorectal cancer according to the three main carcinogenic pathways: Microsatellite instability, CpG island methylator phenotype and Chromosomal instability.

doi:10.1177/1010428320938492

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Article

Characterization of Chilean patients with sporadic colorectal cancer according to the three main carcinogenic pathways: Microsatellite instability, CpG island methylator phenotype and Chromosomal instability.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jul 2020

Wielandt Ana María, Hurtado Claudia, Moreno C Mauricio, Villarroel Cynthia, Castro Magdalena, Estay Marlene, Simian Daniela, Martinez Maripaz, Vial Maria Teresa, Kronberg Udo, López-Köstner Francisco

Abstract excerpt

Molecular classification of colorectal cancer is difficult to implement in clinical settings where hundreds of genes are involved, and resources are limited. This study aims to characterize the molecular subtypes of patients with sporadic colorectal cancer based on the three main carcinogenic pathways microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and chromosomal instability (CIN) in a...

Topics

Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Carcinogenesis
Chile
Chromosomal Instability
Colorectal Neoplasms
CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Methylation

Female

Gene Expression Regulation, Neoplastic

Humans

Male

Microsatellite Instability

Middle Aged

Mutation

Proto-Oncogene Proteins B-raf

Source

Open in PubMed

Identifiers

PMID: 32635826
DOI: 10.1177/1010428320938492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-32635826-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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