Genetic variation in CACNA1C affects neural processing in major depression.

doi:10.1016/j.jpsychires.2014.02.003

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Article

Genetic variation in CACNA1C affects neural processing in major depression.

Journal of psychiatric research - 1 Jun 2014

Backes Heidelore, Dietsche Bruno, Nagels Arne, Konrad Carsten, Witt Stephanie H, Rietschel Marcella, Kircher Tilo, Krug Axel

Abstract excerpt

Genetic studies found the A allele of the single nucleotide polymorphism rs1006737 in the CACNA1C gene, which encodes for the alpha 1C subunit of the voltage-dependent, L-type calcium ion channel Cav1.2, to be overrepresented in patients with major depressive disorder (MDD). Altered prefrontal brain functioning and impaired semantic verbal fluency (SVF) are robust findings in these patients. A recent functional...

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PMID: 24612926
DOI: 10.1016/j.jpsychires.2014.02.003

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