Article
Statistical epistasis and functional brain imaging support a role of voltage-gated potassium channels in human memory.
PloS one - 1 Jan 2011
Heck Angela, Vogler Christian, Gschwind Leo, Ackermann Sandra, Auschra Bianca, Spalek Klara, Rasch Björn, de Quervain Dominique, Papassotiropoulos Andreas
Abstract excerpt
Despite the current progress in high-throughput, dense genome scans, a major portion of complex traits' heritability still remains unexplained, a phenomenon commonly termed "missing heritability." The negligence of analytical approaches accounting for gene-gene interaction effects, such as statistical epistasis, is probably central to this phenomenon. Here we performed a comprehensive two-way SNP interaction...
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