Article
A multiscale model of epigenetic heterogeneity reveals the kinetic routes of pathological cell fate reprogramming
2018-10-24
Abstract excerpt
The inherent capacity of somatic cells to switch their phenotypic status in response to damage stimuli in vivo might have a pivotal role in ageing and cancer. However, how the entry-exit mechanisms of phenotype reprogramming are established remains poorly understood. In an attempt to elucidate such mechanisms, we herein introduce a stochastic model of combined epigenetic regulation (ER)-gene regulatory network (G...
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Identifiers and source
- Literature Corpus work
- c5973a7f-59c8-52d8-9ed7-c5ae5ab376d9
- DOI
- 10.1101/452433