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A Tetraploid Intermediate Precedes Aneuploid Formation in Yeasts Exposed to Fluconazole

18 Mar 2014

Abstract excerpt

Candida albicans, the most prevalent human fungal pathogen, is generally diploid. However, 50% of isolates that are resistant to fluconazole (FLC), the most widely used antifungal, are aneuploid and some aneuploidies can confer FLC resistance. To ask if FLC exposure causes or only selects for aneuploidy, we analyzed diploid strains during exposure to FLC using flow cytometry and epifluorescence microscopy. FLC...

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PMID: 24642609
DOI: 10.1371/journal.pbio.1001815

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