Article
Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury.
Kidney international - 1 Nov 2013
Blattner Simone M, Hodgin Jeffrey B, Nishio Masashi, Wylie Stephanie A, Saha Jharna, Soofi Abdul A, Vining Courtenay, Randolph Ann, Herbach Nadja, Wanke Ruediger, Atkins Kevin B, Gyung Kang Hee, Henger Anna, Brakebusch Cord, Holzman Lawrence B, Kretzler Matthias
Abstract excerpt
Podocytes are highly specialized epithelial cells with complex actin cytoskeletal architecture crucial for maintenance of the glomerular filtration barrier. The mammalian Rho GTPases Rac1 and Cdc42 are molecular switches that control many cellular processes, but are best known for their roles in the regulation of actin cytoskeleton dynamics. Here, we employed podocyte-specific Cre-lox technology and found that...
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