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Article

Loss of genome maintenance accelerates podocyte damage and aging

2020-09-13

Abstract excerpt

DNA repair is essential for preserving genome integrity and ensuring cellular functionality and survival. Podocytes, post-mitotic glomerular epithelial cells, bear limited regenerative capacity, and their survival is indispensable to maintain the function of the kidney’s filtration units. While podocyte depletion is a hallmark of the aging process and of many proteinuric kidney diseases, the underlying factors rem...

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Literature Corpus work
da7e8b0e-43a1-595f-8c0d-89adfb68c406
DOI
10.1101/2020.09.13.295303
Open publication

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Loss of genome maintenance accelerates podocyte damage and agingDOI 10.1101/2020.09.13.295303
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