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Article

Rap1 Activity Is Essential for Focal Adhesion and Slit Diaphragm Integrity

18 Mar 2022

Abstract excerpt

Glomerular podocytes build, with their intercellular junctions, part of the kidney filter. The podocyte cell adhesion protein, nephrin, is essential for developing and maintaining slit diaphragms as functional loss in humans results in heavy proteinuria. Nephrin expression and function are also altered in many adult-onset glomerulopathies. Nephrin signals from the slit diaphragm to the actin cytoskeleton and...

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PMID: 35372328
DOI: 10.3389/fcell.2022.790365

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