Nephrin Signaling Results in Integrin β1 Activation

Abstract excerpt

Significance Statement The slit diaphragm protein Nephrin, which is essential for an intact glomerular filter, signals from the podocyte slit diaphragm to the Actin cytoskeleton and induces lamellipodia formation. The authors present evidence that Nephrin activation results in activation of Integrin β 1 in a cultured human podocyte model, and that C3G, a guanine nucleotide exchange factor of the small GTPase...