Loss of Arhgap24 alters glomerular ultrastructure in zebrafish model.

doi:10.1007/s10157-026-02921-x

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Article

Loss of Arhgap24 alters glomerular ultrastructure in zebrafish model.

Clinical and experimental nephrology - 1 Sept 2026

Saito Koji, Furukawa Fumiya, Kawashima Nagako, Tanaka Manabu, Naito Shokichi

Abstract excerpt

BACKGROUND: ARHGAP24, a GTPase-activating protein (GAP) for the Rho family small GTPase Rac1, is highly expressed in podocytes and is thought to contribute to maintaining glomerular filtration barrier. Variants in ARHGAP24 have been implicated in human kidney diseases. However, the physiological requirement of ARHGAP24 in podocytes remains unclear. Here, we generated an arhgap24 knockout (KO) zebrafish, a...

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Gene Knockout Techniques
GTPase-Activating Proteins
Kidney Glomerulus
Phenotype
Podocytes
Zebrafish
Zebrafish Proteins

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Open in PubMed

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PMID: 42496910
DOI: 10.1007/s10157-026-02921-x

Genes

ARHGAP24

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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