Article

Immunoregulatory macrophages modify local pulmonary immunity and ameliorate hypoxic-pulmonary hypertension

2023-08-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Rationale</h4> Macrophages play a central role in the onset and progression of vascular disease in pulmonary hypertension (PH) and cell-based immunotherapies aimed at treating vascular remodeling are lacking. <h4>Objective</h4> To evaluate the effect of pulmonary administration of macrophages modified to have an anti-inflammatory/pro-resolving phenotype in attenuating early pulmonary infla...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa4dc920-30bd-52c5-9aaa-61daee3569c8
DOI: 10.1101/2023.07.31.551394

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunoregulatory macrophages modify local pulmonary immunity and ameliorate hypoxic-pulmonary hypertensionDOI 10.1101/2023.07.31.551394Read

Immunoregulatory Macrophages Modify Local Pulmonary Immunity and Ameliorate Hypoxic Pulmonary Hypertension.Semantic proximity Read

Regulatory macrophages: setting the threshold for therapy.Semantic proximity Read

Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis.Semantic proximity Read

Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage "Switch" Phenotype.Semantic proximity Read

A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension.Semantic proximity Read

Gremlin 1 is required for macrophage M2 polarizationSemantic proximity Read

Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension.Semantic proximity Read

An optimized protocol for human M2 macrophages using M-CSF and IL-4/IL-10/TGF-β yields a dominant immunosuppressive phenotype.Semantic proximity Read

Functional plasticity of macrophages: reversible adaptation to changing microenvironments.Semantic proximity Read

Macrophages in Tissue Repair, Regeneration, and Fibrosis.Semantic proximity Read

Reversible differentiation of pro- and anti-inflammatory macrophages.Semantic proximity Read

Macrophages in renal disease.Semantic proximity Read