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Article

BRCA2 is required for neurogenesis and suppression of medulloblastoma.

The EMBO journal - 6 Jun 2007

Frappart Pierre-Olivier, Lee Youngsoo, Lamont Jayne, McKinnon Peter J

Abstract excerpt

Defective DNA damage responses in the nervous system can result in neurodegeneration or tumorigenesis. Despite the importance of DNA damage signalling, the neural function of many critical DNA repair factors is unclear. BRCA2 is necessary for homologous recombination repair of DNA and the prevention of diseases including Fanconi Anemia and cancer. We determined the role of BRCA2 during brain development by...

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Source

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Identifiers

PMID: 17476307
DOI: 10.1038/sj.emboj.7601703
PMCID: PMC1888666

Genes

BRCA2
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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