Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BRCA1-associated tumorigenesis: what have we learned from knockout mice?

Trends in genetics : TIG - 1 Oct 2001

Brodie S G, Deng C X

Abstract excerpt

A series of allelic mutations in the tumor suppressor Brca1 have been created to study mechanisms underlying BRCA1-associated tumorigenesis. Brca1 is essential in maintaining genome integrity through its involvement in DNA damage repair, G(2)-M cell-cycle checkpoint and centrosome duplication. The loss of Brca1 is not sufficient for malignant transformation, rather, it triggers multiple genetic alterations,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Breast Neoplasms
Share to Genes, BRCA1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Mammary Neoplasms, Experimental

Share to Mice, Knockout

Share to Models, Biological

Source

Identifiers

PMID: 11585672
DOI: 10.1016/s0168-9525(01)02451-9

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRCA1-associated tumorigenesis: what have we learned from knockout mice?PMID 11585672Read ↗

Mouse models of BRCA1 and their application to breast cancer research.Semantic proximity Read ↗

Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice.Semantic proximity Read ↗

Brca1 Mouse Models: Functional Insights and Therapeutic Opportunities.Semantic proximity Read ↗

Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects.Semantic proximity Read ↗

BRCA1 as tumor suppressor: lord without its RING?Semantic proximity Read ↗

Tumorigenesis as a consequence of genetic instability in Brca1 mutant mice.Semantic proximity Read ↗

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer.Semantic proximity Read ↗

Overview of history and progress in BRCA1 research: the first BRCA1 decade.Semantic proximity Read ↗

Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation.Semantic proximity Read ↗

The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans.Semantic proximity Read ↗

The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.Semantic proximity Read ↗

Generation and analysis of Brca1 conditional knockout mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.