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Article

The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.

Genes & development - 15 Mar 2014

Gerhardt Dawson M, Pajcini Kostandin V, D'altri Teresa, Tu Lili, Jain Rajan, Xu Lanwei, Chen Michael J, Rentschler Stacey, Shestova Olga, Wertheim Gerald B, Tobias John W, Kluk Michael, Wood Antony W, Aster Jon C, Gimotty Phyllis A, Epstein Jonathan A, Speck Nancy, Bigas Anna, Pear Warren S

Abstract excerpt

Notch1 is required to generate the earliest embryonic hematopoietic stem cells (HSCs); however since Notch-deficient embryos die early in gestation, additional functions for Notch in embryonic HSC biology have not been described. We used two complementary genetic models to address this important...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24637115
DOI: 10.1101/gad.227496.113
PMCID: PMC3967047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24637115-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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