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Article

Hematopoietic stem cell fate is established by the Notch-Runx pathway.

Genes & development - 1 Oct 2005

Burns Caroline Erter, Traver David, Mayhall Elizabeth, Shepard Jennifer L, Zon Leonard I

Abstract excerpt

Identifying the molecular pathways regulating hematopoietic stem cell (HSC) specification, self-renewal, and expansion remains a fundamental goal of both basic and clinical biology. Here, we analyzed the effects of Notch signaling on HSC number during zebrafish development and adulthood, defining a critical pathway for stem cell specification. The Notch signaling mutant mind bomb displays normal embryonic...

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Identifiers

PMID: 16166372
DOI: 10.1101/gad.1337005
PMCID: PMC1240042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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