Article
CTLA-4 polymorphisms and clinical outcome after allogeneic stem cell transplantation from HLA-identical sibling donors.
Blood - 1 Jul 2007
Pérez-García Arianne, De la Cámara Rafael, Román-Gómez Jose, Jiménez-Velasco Antonio, Encuentra Maite, Nieto Jose B, de la Rubia Javier, Urbano-Ispizúa Alvaro, Brunet Salut, Iriondo Arturo, González Marcos, Serrano David, Espigado Ildefonso, Solano Carlos, Ribera Josep M, Pujal Josep M, Hoyos Montserrat, Gallardo David
Abstract excerpt
CTLA-4 is an inhibitory molecule that down-regulates T-cell activation. Although polymorphisms at CTLA-4 have been correlated with autoimmune diseases their association with clinical outcome after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has yet to be explored. A total of 5 CTLA-4 single-nucleotide polymorphisms were genotyped on 536 HLA-identical sibling donors of allo-HSC transplants....
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