Article
CTLA-4 polymorphisms and haplotype correlate with survival in ALL after allogeneic stem cell transplantation from related HLA-haplotype-mismatched donor.
Journal of translational medicine - 27 Apr 2016
Qin X-Y, Wang Y, Li G-X, Qin Y-Z, Wang F-R, Xu L-P, Chen H, Han W, Wang J-Z, Zhang X-H, Chang Y-J, Liu K-Y, Jiang Z-F, Huang X-J
Abstract excerpt
BACKGROUND: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been established as an effective treatment for patients with hematological malignancies. Disease relapse remains a major cause of transplant failure. T cell homeostasis is critical to determine the potency of the GVT effect. Recent studies have shown the association of the CTLA-4 polymorphisms with the outcome after HLA-identical...
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