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Article

Temporal control of the dephosphorylation of Cdk substrates by mitotic exit pathways in budding yeast.

Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2008

Jin Fengzhi, Liu Hong, Liang Fengshan, Rizkallah Raed, Hurt Myra M, Wang Yanchang

Abstract excerpt

The temporal phosphorylation of cell cycle-related proteins by cyclin-dependent kinases (Cdks) is critical for the correct order of cell cycle events. In budding yeast, CDC28 encodes the only Cdk and its association with various cyclins governs the temporal phosphorylation of Cdk substrates. S-phase Cdk substrates are phosphorylated earlier than mitotic Cdk substrates, which ensures the sequential order of DNA...

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Identifiers

PMID: 18845678
DOI: 10.1073/pnas.0808719105
PMCID: PMC2570984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Temporal control of the dephosphorylation of Cdk substrates by mitotic exit pathways in budding yeast.PMID 18845678Read ↗

The role of the polo kinase Cdc5 in controlling Cdc14 localization.Semantic proximity Read ↗

Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus.Semantic proximity Read ↗

Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis.Semantic proximity Read ↗

Cdc14 Early Anaphase Release, FEAR, Is Limited to the Nucleus and Dispensable for Efficient Mitotic Exit.Semantic proximity Read ↗

APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus.Semantic proximity Read ↗

DNA damage checkpoints inhibit mitotic exit by two different mechanisms.Semantic proximity Read ↗

Crm1-mediated nuclear export of Cdc14 is required for the completion of cytokinesis in budding yeast.Semantic proximity Read ↗

The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation.Semantic proximity Read ↗

Nucleolar segregation lags behind the rest of the genome and requires Cdc14p activation by the FEAR network.Semantic proximity Read ↗

Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus.Semantic proximity Read ↗

The SIN kinase Sid2 regulates cytoplasmic retention of the S. pombe Cdc14-like phosphatase Clp1.Semantic proximity Read ↗

Fission yeast Clp1p phosphatase affects G2/M transition and mitotic exit through Cdc25p inactivation.Semantic proximity Read ↗

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