Article
Assessment of a proposed "three-criteria" cocaine addiction model for use in reinstatement studies with rats.
Psychopharmacology - 1 Aug 2014
Waters R Parrish, Moorman David E, Young Amy B, Feltenstein Matthew W, See Ronald E
Abstract excerpt
RATIONALE: Relapse is a primary obstacle in the treatment of addiction disorders, and as such, understanding this phenomenon is a major effort of clinical and preclinical studies of cocaine addiction. OBJECTIVE: A recently developed protocol uses laboratory rats to model cocaine addiction by examining three criteria of addiction-like behaviors (persistent seeking in the absence of drug, high motivation for drug,...
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