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Article

The psychogenetically selected Roman high- and low-avoidance rat lines: a model to study the individual vulnerability to drug addiction.

Neuroscience and biobehavioral reviews - 1 Jan 2007

Giorgi Osvaldo, Piras Giovanna, Corda Maria G

Abstract excerpt

The Roman high- (RHA) and low-avoidance (RLA) rat lines were selected for, respectively, rapid vs poor acquisition of two-way active avoidance in the shuttle-box. Here, we review experimental evidence indicating that, compared with their RLA counterparts, RHA rats display a robust sensation/novelty seeking profile, a marked preference and intake of natural or drug rewards, and more pronounced behavioral and...

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Source

Identifiers

PMID: 17164110
DOI: 10.1016/j.neubiorev.2006.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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