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Article

Natural polymorphisms and unusual mutations in HIV-1 protease with potential antiretroviral resistance: a bioinformatic analysis.

BMC bioinformatics - 15 Mar 2014

Mata-Munguía Carlos, Escoto-Delgadillo Martha, Torres-Mendoza Blanca, Flores-Soto Mario, Vázquez-Torres Mildred, Gálvez-Gastelum Francisco, Viniegra-Osorio Arturo, Castillero-Manzano Marcelo, Vázquez-Valls Eduardo

Abstract excerpt

BACKGROUND: The correlations of genotypic and phenotypic tests with treatment, clinical history and the significance of mutations in viruses of HIV-infected patients are used to establish resistance mutations to protease inhibitors (PIs). Emerging mutations in human immunodeficiency virus type 1 (HIV-1) protease confer resistance to PIs by inducing structural changes at the ligand interaction site. The aim of...

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PMID: 24629078
DOI: 10.1186/1471-2105-15-72
PMCID: PMC4003850

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