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Article

Characterization of clinical predictors of naturally occurring NS3/NS4A protease polymorphism in genotype 1 hepatitis C virus mono and HIV co-infected patients.

Journal of medical virology - 1 Dec 2017

Lisboa Neto Gaspar, Malta Fernanda M, Gomes-Gouvêa Michele S, Noble Caroline F, Romano Camila M, Rebello Pinho João R, Silva Mariliza H, Leite Andrea G B, Piccoli Leonora Z, Carrilho Flair J, Mendes-Correa Maria C

Abstract excerpt

Spontaneously occurring resistance may impair the success of protease inhibitors based regimens in HCV treatment. This study aimed to evaluate associations between amino acid substitutions in NS3/NS4A domain and clinical features of 247 HCV mono or HCV/HIV co-infected patients. Fourteen samples (5.7%) harbored at least one resistance-associated substitution (RAS). The following RASs were detected in NS3 region:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28700085
DOI: 10.1002/jmv.24900

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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