Article
Drug resistance mutations and newly recognized treatment-related substitutions in the HIV-1 protease gene: prevalence and associations with drug exposure and real or virtual phenotypic resistance to protease inhibitors in two clinical cohorts of antiretroviral experienced patients.
Journal of medical virology - 1 Sept 2004
Torti Carlo, Quiros-Roldan Eugenia, Monno Laura, Patroni Andrea, Saracino Annalisa, Angarano Gioacchino, Tinelli Carmine, Lo Caputo Sergio, Tirelli Valeria, Mazzotta Francesco, Carosi Giampiero
Abstract excerpt
This study aimed at identifying HIV-1 protease amino acid changes associated with protease inhibitor (PI) exposure and susceptibility. New amino acid substitutions were correlated with the number of experienced PIs, reaching statistical significance only for those at positions 3, 44, and 74. The correspondence multivariate model demonstrated that > or =3 experienced PIs and substitutions or mutations at positions...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.