Article
Simple algorithm derived from a geno-/phenotypic database to predict HIV-1 protease inhibitor resistance.
AIDS (London, England) - 18 Aug 2000
Schmidt B, Walter H, Moschik B, Paatz C, van Vaerenbergh K, Vandamme A M, Schmitt M, Harrer T, Uberla K, Korn K
Abstract excerpt
BACKGROUND: Resistance against protease inhibitors (PI) can either be analysed genotypically or phenotypically. However, the interpretation of genotypic data is difficult, particularly for PI, because of the unknown contributions of several mutations to resistance and cross-resistance. OBJECTIVE:...
Topics
- Acquired Immunodeficiency Syndrome
- Algorithms
- Databases, Factual
- Drug Resistance, Microbial
- Genotype
- HIV Protease Inhibitors
- HIV-1
- Humans
- Molecular Sequence Data
- Phenotype
- Point Mutation
- Sensitivity and Specificity