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Article

Novel human immunodeficiency virus type 1 protease mutations potentially involved in resistance to protease inhibitors.

Antimicrobial agents and chemotherapy - 1 May 2005

Svicher Valentina, Ceccherini-Silberstein Francesca, Erba Fulvio, Santoro Maria, Gori Caterina, Bellocchi Maria Concetta, Giannella Sara, Trotta Maria Paola, Monforte Antonella d'Arminio, Antinori Andrea, Perno Carlo Federico

Abstract excerpt

Plasma-derived sequences of human immunodeficiency virus type 1 (HIV-1) protease from 1,162 patients (457 drug-naive patients and 705 patients receiving protease inhibitor [PI]-containing antiretroviral regimens) led to the identification and characterization of 17 novel protease mutations potentially associated with resistance to PIs. Fourteen mutations were positively associated with PIs and significantly...

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Identifiers

PMID: 15855527
DOI: 10.1128/AAC.49.5.2015-2025.2005
PMCID: PMC1087636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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