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Article

Computational Prediction of HIV-1 Resistance to Protease Inhibitors.

Journal of chemical information and modeling - 23 May 2016

Hosseini Ali, Alibés Andreu, Noguera-Julian Marc, Gil Victor, Paredes Roger, Soliva Robert, Orozco Modesto, Guallar Victor

Abstract excerpt

The development of mutations in HIV-1 protease (PR) hinders the activity of antiretroviral drugs, forcing changes in drug prescription. Most resistance assessments used to date rely on expert-based rules on predefined sets of stereotypical mutations; such an information-driven approach cannot capture new polymorphisms or be applied for new drugs. Computational modeling could provide a more general assessment of...

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PMID: 27082876
DOI: 10.1021/acs.jcim.5b00667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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