Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase.

AIDS (London, England) - 19 Feb 2008

Kearney Mary, Palmer Sarah, Maldarelli Frank, Shao Wei, Polis Michael A, Mican JoAnn, Rock-Kress Diane, Margolick Joseph B, Coffin John M, Mellors John W

Abstract excerpt

BACKGROUND: Failure of antiretroviral therapy may result from the selection of pre-existing, drug-resistant HIV-1 variants, but the frequency and type of such variants have not been defined. OBJECTIVE: We used single genome sequencing (SGS) to characterize the frequency of polymorphism at drug resistance sites in protease (PR) and reverse transcriptase (RT) in plasma samples from antiretroviral naive individuals....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Viral
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Infections

Share to HIV Protease

Share to HIV Reverse Transcriptase

Share to Mutation

Share to Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 18301062
DOI: 10.1097/QAD.0b013e3282f29478
PMCID: PMC2921824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase.PMID 18301062Read ↗

HIV-1 Protease, Reverse Transcriptase, and Integrase Variation.Semantic proximity Read ↗

Natural polymorphisms and unusual mutations in HIV-1 protease with potential antiretroviral resistance: a bioinformatic analysis.Semantic proximity Read ↗

Profiling resistance-related mutations in the protease region of the pol gene: single genome sequencing of HIV in plasma and peripheral blood mononuclear cells.Semantic proximity Read ↗

HIV-1 protease and reverse transcriptase mutations for drug resistance surveillance.Semantic proximity Read ↗

Highly diversified multiply drug-resistant HIV-1 quasispecies in PBMCs: a case report.Semantic proximity Read ↗

Drug resistance mutations in HIV provirus are associated with defective proviral genomes with hypermutation.Semantic proximity Read ↗

[Detection of resistance mutations in proviral DNA in HIV-1 infection].Semantic proximity Read ↗

Systematic evaluation of allele-specific real-time PCR for the detection of minor HIV-1 variants with pol and env resistance mutations.Semantic proximity Read ↗

Frequency of antiretroviral drug resistance mutations in HIV-1 strains from patients failing triple drug regimens. The Terry Beirn Community Programs for Clinical Research on AIDS.Semantic proximity Read ↗

Analysis of unusual and signature APOBEC-mutations in HIV-1 pol next-generation sequences.Semantic proximity Read ↗

HIV-2 protease sequences of subtypes A and B harbor multiple mutations associated with protease inhibitor resistance in HIV-1.Semantic proximity Read ↗

The role of polymorphisms at position 89 in the HIV-1 protease gene in the development of drug resistance to HIV-1 protease inhibitors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.