Article
Frequent polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase.
AIDS (London, England) - 19 Feb 2008
Kearney Mary, Palmer Sarah, Maldarelli Frank, Shao Wei, Polis Michael A, Mican JoAnn, Rock-Kress Diane, Margolick Joseph B, Coffin John M, Mellors John W
Abstract excerpt
BACKGROUND: Failure of antiretroviral therapy may result from the selection of pre-existing, drug-resistant HIV-1 variants, but the frequency and type of such variants have not been defined. OBJECTIVE: We used single genome sequencing (SGS) to characterize the frequency of polymorphism at drug re...
Topics
- Adult
- Drug Resistance, Viral
- Female
- Genotype
- HIV Infections
- HIV Protease
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Male
- Mutation
- Polymorphism, Genetic