Article
Novel drug resistance mutations in HIV: recognition and clinical relevance.
AIDS reviews - 1 Jan 2000
Perno Carlo Federico, Svicher Valentina, Ceccherini-Silberstein Francesca
Abstract excerpt
During its spread among humans, HIV-1 has developed an extraordinary degree of genetic diversity. The pol region encoding for viral enzymes such as the reverse transcriptase and the protease, and the env region encoding for the viral glycoprotein gp41 are subjected not only to natural variation, but also to the selection pressure imposed by the pharmacologic treatment. Under these conditions in HIV-1 infected...
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