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Article

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner

13 Mar 2014

Abstract excerpt

Cells encountering hypoxic stress conserve resources and energy by downregulating the protein synthesis. Here we demonstrate that one mechanism in this response is the translational repression of TOP mRNAs that encode components of the translational apparatus. This mode of regulation involves TSC and Rheb, as knockout of TSC1 or TSC2 or overexpression of Rheb rescued TOP mRNA translation in oxygen-deprived cells....

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PMID: 24627160
DOI: 10.1093/jmcb/mju008

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Related research

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Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent mannerPMID 24627160Read ↗

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Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions.Semantic proximity Read ↗

Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1.Semantic proximity Read ↗

Distinct Functions of the Tor1 and Tor2 Kinases in Regulation of the Ribosomal Protein Gene Expression via TORC1, Not TORC2.Semantic proximity Read ↗

Two distinct nodes of translational inhibition in the Integrated Stress ResponseSemantic proximity Read ↗

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses.Semantic proximity Read ↗

Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAsSemantic proximity Read ↗

The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation.Semantic proximity Read ↗

Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAsSemantic proximity Read ↗

Translational control of gene expression during hypoxiaSemantic proximity Read ↗

Biased regulation of protein synthesis and hypoxic death by a conditional raptor mutation.Semantic proximity Read ↗

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