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Article

The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.

Cell death and differentiation - 1 Jan 2011

Kang Y J, Lu M-K, Guan K-L

Abstract excerpt

Tuberous sclerosis complex (TSC)1 and TSC2 are tumor suppressors that inhibit cell growth and mutation of either gene causes benign tumors in multiple tissues. The TSC1 and TSC2 gene products form a functional complex that has GTPase-activating protein (GAP) activity toward Ras homolog enriched i...

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Source

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Identifiers

PMID: 20616807
DOI: 10.1038/cdd.2010.82
PMCID: PMC3131877

Genes

TSC1
TSC2
ATF4
ATF6
EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20616807-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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