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Distinct Functions of the Tor1 and Tor2 Kinases in Regulation of the Ribosomal Protein Gene Expression via TORC1, Not TORC2.

Molecular and cellular biology - 1 Jan 2026

Kaja Amala, Uprety Bhawana, Chakraborty Pritam, Bhaumik Sukesh R

Abstract excerpt

The serine/threonine kinase, TOR (target of rapamycin), exists in two complexes, namely TORC1 (with either Tor1 or Tor2 kinase) and TORC2 (that contains Tor2, but not Tor1), and its pharmacological inhibition by rapamycin impairs the PIC (pre-initiation complex) formation at the ribosomal protein genes (and hence transcription and ribosome biogenesis). However, TOR's involvement in such gene regulation has not...

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PMID: 41343340
DOI: 10.1080/10985549.2025.2587084

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