Article
TET proteins and 5-methylcytosine oxidation in the immune system.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2013
Tsagaratou Ageliki, Rao Anjana
Abstract excerpt
DNA methylation in the form of 5-methylcytosine (5mC) is essential for normal development in mammals and influences a variety of biological processes, including transcriptional regulation, imprinting, and the maintenance of genomic stability. The recent discovery of TET proteins, which oxidize 5mC to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine, has changed our understanding of the process of...
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