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Article

The response to interferon is influenced by hepatitis B virus genotype in vitro and in vivo.

Virus research - 1 Jan 2013

Zhang Yuhua, Wu Yiqi, Ye Shengqian, Wang Tianzhen, Zhao Ran, Chen Fulai, Abe Kenji, Jin Xiaoming

Abstract excerpt

PURPOSE: To investigate the effectiveness of an interferon administration on different genotypes of hepatitis B virus (HBV) in vitro and in vivo. METHODS: In vitro, we transfected plasmids carrying different HBV genotypes including recently identified new genotype I into HepG2 and HuH7 cells, then treated with standard interferon alpha (IFN-α); in vivo, we treated mice with pegylated interferon alpha (Peg-IFN-α)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23123214
DOI: 10.1016/j.virusres.2012.10.027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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