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Article

Development and characterization of a chronic hepatitis B murine model with a mutation in the START codon of an HBV polymerase.

Physiological research - 8 Mar 2023

Vanekova L, Polidarova M, Charvat V, Vavrina Z, Veverka V, Birkus G, Brazdova A

Abstract excerpt

Chronic hepatitis B (CHB) is caused by the Hepatitis B virus (HBV) and affects millions of people worldwide. Developing an effective CHB therapy requires using in vivo screening methods, such as mouse models reflecting CHB based on hydrodynamic delivery of plasmid vectors containing a replication-competent HBV genome. However, long-term expression of HBV proteins is accompanied by production of progeny virions,...

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Identifiers

PMID: 36545874
DOI: 10.33549/physiolres.934979
PMCID: PMC10069812

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